Choline hydroxide
(2-HYDROXYETHYL)TRIMETHYLAMMONIUM HYDROXIDE
CAS: 123-41-1
Molecular Formula: C5H15NO2
Choline hydroxide - Names and Identifiers
| Name | (2-HYDROXYETHYL)TRIMETHYLAMMONIUM HYDROXIDE |
| Synonyms | fagine bursine choline,solution Choline hydroxide (2-HYDROXYETHYL)TRIMETHYLAMMONIUM HYDROXIDE 2-hydroxy-n,n,n-trimethyl-ethanaminiuhydroxide CHOLINE CHOLINE BASE CHOLINE HYDROXIDE L-URIDINE |
| CAS | 123-41-1 |
| EINECS | 204-625-1 |
| InChIKey | KIZQNNOULOCVDM-UHFFFAOYSA-M |
Choline hydroxide - Physico-chemical Properties
| Molecular Formula | C5H15NO2 |
| Molar Mass | 121.18 |
| Density | 1.09 g/mL at 20 °C |
| Melting Point | 236～239℃ |
| Flash Point | 92 °F |
| Water Solubility | miscible |
| Appearance | Shape Granular Powder, color White |
| pKa | 13.9(at 25℃) |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.4304 |
| Physical and Chemical Properties | Strongly alkaline, viscous liquid or crystal. Soluble in water and alcohol, insoluble in ether. In acidic solution on the thermal stability, easy to absorb carbon dioxide in the air, water absorption is very strong, heat decomposition. The taste was bitter. |
| Use | Choline, or hydroxyethyl trimethylamine, is a quaternary amine base, colorless crystals or colorless bitter water-soluble white slurry, has a strong hygroscopicity, exposure to air can quickly absorb water. Choline readily reacts with acids to form more stable crystalline salts (e. G. Choline chloride), which are also unstable under strong alkaline conditions, but are relatively stable to heat and storage. As an organic strong base, can be completely ionized in water, metal content is low. Its chemical properties make choline widely used in chemical and semiconductor fields. |
Choline hydroxide - Risk and Safety
| Risk Codes | R34 - Causes burns R35 - Causes severe burns R43 - May cause sensitization by skin contact R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R10 - Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3286 3/PG 2 |
| WGK Germany | 1 |
| RTECS | GA4025500 |
| FLUKA BRAND F CODES | 8-9-23 |
| TSCA | Yes |
| HS Code | 29231000 |
| Hazard Class | 8 |
| Packing Group | II |
Choline hydroxide - Upstream Downstream Industry
Choline hydroxide - Central Cholinergic mechanisms of learning and memory
Last Update：2024-01-02 23:10:35
Choline hydroxide - Research progress on cholinergic theory of Alzheimer's disease
from VIP
Author:
zhongchongbo , Xu Xianghua , Wang Xiaoliang
Abstract:
The central cholinergic system is involved in the regulation of neuronal excitability, cortical plasticity and learning and memory processes in mammals, and is closely related to brain cognitive function. Alzheimer's disease (AD) is the most common cause of Alzheimer's disease, mainly manifested as progressive cognitive decline. Central cholinergic system dysfunction caused by basal forebrain cholinergic injury is the basis of cognitive dysfunction in AD patients. There is a vicious cycle in the course of AD, namely, the early damage of cholinergic neurotransmission in the brain, leading to the production of a large amount of Ap in the vulnerable area of neurodegenerative diseases and the hyperphosphorylation of tau protein, however, Aβ further weakens the effect of cholinergic neurotransmission, and central cholinergic dysfunction may be the root of cognitive dysfunction in AD patients.
Key words:
Alzheimer's disease acetylcholine central cholinergic system dementia
DOI:
10.3321/j.issn:1001-1978.2003.07.003
cited:
year:
2003
Last Update：2023-08-16 22:05:47
Choline hydroxide - Transformation of Choline dehydrogenase gene and identification of salt tolerance in transgenic tomato
from VIP Journal Professional Edition
Author:
Shufang Wang , Wang Junling , Zhao Yanxiu , Zhang hui
Abstract:
using PCR method from E. The Choline dehydrogenase (CDH) gene (betA) was amplified from coliTG1 strain, and its amino acid coding sequence is consistent with the data in the literature, and can be correctly expressed in the prokaryotic expression vector pBV2 2 1, and showed activity. The plant expression framework pRbA of the gene was constructed, and the tomato was transformed by Agrobacterium-mediated leaf disc method. The PCR, Southern and RT PCR analysis of transgenic tomato confirmed that betA had been integrated into the tomato genome, the salt tolerance of transgenic tomato was higher than that of control tomato.
Key words:
Choline dehydrogenase gene transgenic tomato salt tolerance
cited:
year:
2001
Last Update：2023-08-16 22:05:47
Choline hydroxide - Nature
| Merck | 14,2204 |
| EPA chemical information | Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, hydroxide (123-41-1) |
Last Update：2024-04-09 20:45:29
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Raw Materials for Choline hydroxide
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